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KMID : 1225720200120010072
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Allergy, Asthma & Immunology Research : AAIR
2020 Volume.12 No. 1 p.72 ~ p.85
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Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification
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Jung Sung-Su
Lee So-Yeon
Yoon Ji-Sun
Cho Hyun-Ju
Kim Young-Ho
Suh Dong-In
Yang Song-I
Kwon Ji-Won
Jang Gwang-Cheon
Sun Yong-Han
Woo Sung-Il
Youn You-Sook
Park Kang-Seo
Lee Eun
Cho Hwa-Jin
Kook Myung-Hee
Yi Hye-Ryoung
Chung Hai-Lee
Kim Ja-Hyeong
Kim Hyung-Young
Jung Jin-A
Woo Hyang-Ok
Lee Jeom-Kyu
Chang Woo-Sung
Do Nam-Hee
Cho Hye-Joo
Hong Soo-Jong
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Abstract
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Purpose: Data are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and comorbidities, including sensitization to specific allergens and BHR, for the AR phenotype by AR and its Impact on Asthma (ARIA) classification in a general population-based birth cohort study.
Methods: We enrolled 606 children aged 7 years from the Panel Study of Korean Children. The AR phenotype was assigned in accordance with the ARIA classification in children. Skin prick tests and Provocholine provocation test were performed. Risk factors and comorbidities for AR phenotypes were then analyzed.
Results: The prevalence of mild and moderate to severe AR in our study cohort was 37.2% and 8.8%, respectively. Recent use of analgesics or antipyretics and current cat ownership were associated with the risk of mild persistent AR. Sensitizations to Dermatophagoides Pteronyssinus (Der p), Japanese hop and cat were associated with moderate to severe persistent AR. Children with moderate to severe AR had a higher risk of current asthma and BHR compared to mild AR cases (adjusted odds ratio [aOR], 5.26; 95% confidence interval [CI], 1.77?15.62). Moderate to severe AR with allergic sensitization was associated with the highest risk of BHR (aOR, 11.77; 95% CI, 3.40?40.74).
Conclusions: Moderate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management.
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KEYWORD
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Allergic rhinitis, classification, risk factor, child, phenotype, bronchial hyperreactivity, cohort study, prevalence
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